Insoluble Dietary Fiber from Okara Combined with Intermittent Fasting Treatment Synergistically Confers Antiobesity Effects by Regulating Gut Microbiota and Its Metabolites

• DOI: 10.1021/acs.jafc.3c03948
• Publication Date: 2023-08-31T18:37:35Z
• Authors: Sainan Wang; Junyao Wang; Jiarui Zhang; Wenhao Liu; Wendan Jing; Bo Lyu; Hansong Yu; Zhao Zhang
• Keywords: Dysbiosis; Dyslipidemia

Insoluble dietary fiber (IDF) was recently revealed to have an antiobesity impact. However, the impact and potential mechanism of high-purity IDF derived from okara (HPSIDF) on obesity caused by a high-fat diet (HFD) remain unclear. Except for supplementation, intermittent fasting (IF) has attracted extensive interest as new strategy against obesity. Thus, we hypothesize that HPSIDF combined with IF treatment may be more effective in preventing In this study, synergistically alleviated HFD-induced dyslipidemia, impaired glucose homeostasis, systemic inflammation, fat accumulation. Furthermore, gut microbiota dysbiosis lowered short-chain fatty acid synthesis were recovered treatment. Meanwhile, metabolomic analysis feces obviously reversed alterations metabolic pathways differential metabolites induced HFD, which linked modulations microbiota. Collectively, our findings indicated great substantially enhance efficacy modulating its metabolites.