Identification of the Bioavailable Peptidome of Chia Protein Hydrolysate and the In Silico Evaluation of Its Antioxidant and ACE Inhibitory Potential

• DOI: 10.1021/acs.jafc.3c05331
• Publication Date: 2024-02-02T11:13:16Z
• Authors: Alvaro Villanueva; Fernando Rivero-Pino; Maria E. Martin; Teresa Gonzalez-d...; Sergio Montserrat...; Maria C. Millan-L...
• Keywords: Identification

The incorporation of novel, functional, and sustainable foods in human diets is increasing because their beneficial effects environmental-friendly nature. Chia (Salvia hispanica L.) has proved to be a suitable source bioactive peptides via enzymatic hydrolysis. These could responsible for modulating several physiological processes if able reach the target organ. bioavailable contained hydrolysate obtained with Alcalase, as functional foods, were identified using transwell system Caco-2 cell culture absorption model. Furthermore, 20 unique molecular weight lower than 1000 Da higher statistical significance peptide-precursor spectrum match (−10 log P) assessed by silico tools suggest which those exerting demonstrated bioactivity. From characterized peptides, considering features results obtained, AGDAHWTY, VDAHPIKAM, PNYHPNPR, ALPPGAVHW are anticipated contributing antioxidant and/or ACE inhibitor activity chia protein hydrolysates.