Natural Sweetener, Glycyrrhetinic Acid 3-O-Mono-beta-d-glucuronide, for Postprandial Hyperglycemia Management
Nutraceutical
DOI:
10.1021/acs.jafc.3c07188
Publication Date:
2024-02-09T18:18:15Z
AUTHORS (4)
ABSTRACT
This study examines the inhibitory effects of a range sweeteners on α-glucosidase. Our findings revealed that only one natural sweetener, namely, glycyrrhetinic acid 3-O-mono-beta-d-glucuronide (GAMG), derived from licorice, exhibited mixed-type inhibition against α-glucosidase with IC50 value 0.73 ± 0.05 mg/mL. The fluorescence intensity was quenched by GAMG in formation an α-glucosidase–GAMG complex. has been shown to induce conformational changes α-glucosidase, likely through hydrogen bonding, van der Waals force, and alkyl–alkyl interactions amino residues, including Arg 281, Leu 283, Trp 376, Asp 404, 443, 481, 518, Phe 525, Ala 555, 616. Additional animal validation experiments demonstrated slowed starch digestion, thereby attenuating postprandial glycemic response. Taken together, these provide evidence is sweetener potent activity selectively targets supports use as which holds high biological may be beneficial for managing hyperglycemia.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (36)
CITATIONS (5)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....