Ginsenoside Rk3 Ameliorates Obesity-Induced Colitis by Modulating Lipid Metabolism in C57BL/6 Mice

• DOI: 10.1021/acs.jafc.3c08253
• Publication Date: 2024-02-01T17:52:05Z
• Authors: Weimin Wang; Hongwei Chen; Wenyuan Zhang; Daidi Fan; Jianjun Deng; Haixia Yang
• Keywords: Fatty Acid Metabolism

Lipid metabolism is closely related to obesity and its complications. Our previous study found that ginsenoside Rk3 (Rk3), a natural bioactive substance derived from ginseng, can effectively alleviate obesity-induced colitis, while impact on the improvement of lipid disorder remains unclear. Here, we demonstrated significantly alleviated inflammation, oxidative stress, dysregulation in high-fat diet-induced colitis C57BL/6 mice. The potential mechanism by which mitigated colon inflammation context may involve modulation polyunsaturated fatty acid with specific attention n-6 acids, linoleic acid, arachidonic acid. intervention markedly reduced production pro-inflammatory factors (PGE2, PGD2, TXB2, HETE, HODE) inhibiting cyclooxygenase lipoxygenase pathways, enhancing anti-inflammatory (EET diHOME) via cytochrome P450 pathways. findings suggest drug improve intestinal regulating metabolism.