Theabrownin as a Potential Prebiotic Compound Regulates Lipid Metabolism via the Gut Microbiota, Microbiota-Derived Metabolites, and Hepatic FoxO/PPAR Signaling Pathways

• DOI: 10.1021/acs.jafc.3c08541
• Publication Date: 2024-04-03T13:07:34Z
• Authors: Yue Xiao; Dongmei Yang; Haoran Zhang; Huan Guo; Ying Liao; Changhong Lian; Yuqin Yao; Hong Gao; Yina Huang
• Keywords: Prebiotic; Metabolic pathway; Microbial Metabolism

The dysregulation of lipid metabolism poses a significant health threat, necessitating immediate dietary intervention. Our previous research unveiled the prebiotic-like properties theabrownin. This study aimed to further investigate theabrownin-gut microbiota interactions and their downstream effects on using integrated physiological, genomic, metabolomic, transcriptomic approaches. results demonstrated that theabrownin significantly ameliorated dyslipidemia, hepatic steatosis, systemic inflammation induced by high-fat/high-cholesterol diet (HFD). Moreover, improved HFD-induced gut dysbiosis alterations in microbiota-derived metabolites. Additionally, detailed interplay between was revealed. Analysis transcriptome indicated FoxO PPAR signaling pathways played pivotal roles response interactions, primarily through upregulating