Glycyrol Relieves Ulcerative Colitis by Promoting the Fusion of ZO-1 with the Cell Membrane through the Enteric Glial Cells GDNF/RET Pathway

• DOI: 10.1021/acs.jafc.4c00239
• Publication Date: 2024-06-11T19:25:08Z
• Authors: Shangyun Lu; Yang Xu; Huixia Zhang; Ziling Liu; Jiali Xu; Bowen Zheng; Dongxing Shi; Fubin Qiu
• Keywords: Intestinal mucosa; Intestinal epithelium

The damage to the mechanical barrier of intestinal mucosa is initiating factor and core link progression ulcerative colitis (UC). Protecting great significance for improving health status UC patients. ZO-1 a key scaffold protein mucosa, its fusion with membrane epithelium necessary condition maintain integrity mucosa. Enteric glial cells (EGCs) play an important role in maintenance homeostasis have become new target regulating recent years. In this study, we found that glycyrol (GC), representative coumarin compound isolated from Licorice (