Structural Simplification of Podophyllotoxin: Discovery of γ-Butyrolactone Derivatives as Novel Antiviral Agents for Plant Protection

• DOI: 10.1021/acs.jafc.4c04312
• Publication Date: 2024-08-06T21:22:47Z
• Authors: Dan Xu; Yuan Chi; Hong-Wei He; Cai-Yun Chen; Huan Zhou; Xili Liu; Gong Xu
• Keywords: Lead compound

Natural products are a valuable resource for the discovery of novel crop protection agents. A series γ-butyrolactone derivatives, derived from simplification podophyllotoxin's structure, were synthesized and assessed their efficacy against tobacco mosaic virus (TMV). Several derivatives exhibited notable antiviral properties, with compound