Dietary Methionine Restriction Alleviates Cognitive Impairment in Alzheimer’s Disease Mice via Sex-Dependent Modulation on Gut Microbiota and Tryptophan Metabolism: A Multiomics Analysis

• DOI: 10.1021/acs.jafc.4c09878
• Publication Date: 2025-01-02T15:47:48Z
• Authors: Yuyu Zhang; Tianqi Liu; Fei Pan; Yiju Li; Da Wang; Jingxi Pang; Haojie Sang; Yujia Xi; Lin Shi; Zhigang Liu

Plant-based foods with low methionine contents have gained increasing interest for their potential health benefits, including neuroprotective effects. Methionine restriction (MR) linked to a plant-based diet has been shown mitigate neurodegenerative diseases such as Alzheimer's disease (AD) through mechanisms that involve the gut microbiota. In this study, 16-week MR (0.17% methionine,