Polysaccharides of Trametes versicolor Improve Bone Properties in Diabetic Rats

• DOI: 10.1021/acs.jafc.5b02668
• Publication Date: 2015-08-26T11:54:50Z
• Authors: Chung-Hwan Chen; Lin Kang; Hui-Chen Lo; Tai-Hao Hsu; Fang-Yi Lin; Yi-Shan Lin; Zai-Jie Wang; Shih-Tse Chen; Chwan-Li Shen
• Keywords: Blood Glucose; Male; Trametes; 0301 basic medicine; Tibia; Plant Extracts; Biomechanical Phenomena; Diabetes Mellitus, Experimental; Rats; 03 medical and health sciences; Polysaccharides; Animals; Humans; Femur; Bone Diseases; Rats, Wistar

This study investigates the effects of Trametes versicolor (L.:Fr.) Pilát (TVP, also known as Yunzhi) on bone properties in diabetic rats. Forty-five male Wistar rats (8 weeks old) were fed either a chow diet (control) or a high-fat diet throughout the study period of 28 days. Animals in the high-fat-diet group were injected with nicotinamide and streptozotocin to induce diabetes mellitus (DM). The DM rats were divided into a group receiving distilled water (vehicle) and another group receiving TVP at 0.1 g/kg weight by gavage. Relative to the vehicle group, TVP gavage lowered postprandial blood sugar (225 ± 18 mg/dL for TVP vs 292 ± 15 mg/dL for vehicle, p < 0.001) on day 26. Compared to the vehicle group, TVP mitigated DM-induced bone deterioration as determined by increasing bone volume of proximal tibia (22.8 ± 1.4% for TVP vs 16.8 ± 1.3% for vehicle, p = 0.003), trabecular number (p = 0.011), and femoral bone strength (11% in maximal load, 22% in stiffness, 14% in modulus, p < 0.001), and by reducing loss of femoral cortical porosity by 25% (p < 0.001). Our study demonstrates the protective effect of TVP on bone properties was mediated through, in part, the improvement of hyperglycemic control in DM animals.