Erythritol Attenuates Postprandial Blood Glucose by Inhibiting α-Glucosidase

• DOI: 10.1021/acs.jafc.7b05033
• Publication Date: 2018-01-24T02:48:24Z
• Authors: Huaixiu Wen; Bowen Tang; Alan J. Stewart; Yanduo Tao; Yun Shao; Yulei Cui; Huilan Yue; Jinjin Pei; Zenggen Liu; Lijuan Mei; Ruitao Yu; Lei Jiang
• Keywords: Erythritol

Diabetes mellitus (DM) is a serious metabolic disorder, where impaired postprandial blood glucose regulation often leads to severe health complications. The natural chemical erythritol C4 polyol approved by the U.S. Food and Drug Administration for use as sweetener. Here, we examined potential role in control of levels DM. An anti-postprandial hyperglycemia effect upon administration (500 mg kg-1) was demonstrated alloxan-induced DM model mice monitoring changes after intragastric drugs starch. We also found that most likely exerts its hyperglycemic activities inhibiting α-glucosidase competitive manner. This supported enzyme activity assays molecular modeling experiments. In latter experiments, it possible successfully dock into catalytic pocket α-glucosidase, with resultant interaction driven electrostatic interactions involving Asp215, Asp69, Arg446 residues. study suggests may not only serve substitute but be useful agent treatment help manage levels.