Development of Multifunctional Avermectin Poly(succinimide) Nanoparticles to Improve Bioactivity and Transportation in Rice

• DOI: 10.1021/acs.jafc.8b03295
• Publication Date: 2018-10-09T17:59:29Z
• Authors: Guodong Wang; Yuyan Xiao; Hanhong Xu; Pengtong Hu; Wenlong Liang; Lijuan Xie; Jinliang Jia
• Keywords: Avermectin; Nanocarriers; Succinimides

Avermectin (AVM) as a nonsystemic pesticide possesses low effective utilization rate. Studies of the multifunctional delivery system for improving biological activity are developing prosperously. In this study, avermectin/polysuccinimide with glycine methyl ester nanoparticles (AVM-PGA) were prepared by self-assembly process. The AVM loading capacity was up to 23.7%. After 24 h UV irradiation, there still about 70% remaining in PGA42 nanocarriers, opposed less than 5% free-form AVM. rising ambient pH promoted release using an vitro releasing test, revealing favorable pH-responsively controlled-release property. mortality rate Plutella xylostella 2.5 μg/mL content AVM-PGA42 96.3% after 48 h, while that free only 51.5%. addition, could be detected stems and all leaves treated nanoparticles, whereas rare AVM, which achieved transportation nanocarriers carrying rice first time. Furthermore, PGA performed good growth promoting effect on rice. These results show nanopesticides have great potential application prospect control pest improve drug efficiency agriculture.