Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-κB in Male C57BL/6J Mice and BV2 Microglial Cells

• DOI: 10.1021/acs.jafc.8b03731
• Publication Date: 2018-09-13T08:07:50Z
• Authors: Pandi He; Shikai Yan; Jiaojiao Zheng; Yuxing Gao; Shuhan Zhang; Zhigang Liu; Xuebo Liu; Chunxia Xiao
• Keywords: Eriodictyol

Eriodictyol, a natural flavonoid mainly distributed in citrus fruits and peanut, has been well-documented with possession of excellent anti-inflammatory, antioxidant, anticancer bioactivities. This work focus on the protective effects eriodictyol LPS-induced neuroinflammation, amyloidogenesis, cognitive impairment, potential mechanisms involved. Behavioral tests histological examinations showed that significantly prevented memory neuronal damage triggered by LPS. Consistently, (100 mg/kg) reduced formation Aβ1–42 28.37 ± 16.71 pg/mL compared to LPS group. In addition, high dose also equilibrated cholinergic system via suppressing AChE activity (0.1996 0.0831 U/mgprot) elevating ChAT (41.81 24.72 U/g) as well ACh level (5.093 3.531 μg/mgprot) Western blot results indicated group, suppressed glial overactivation (84.29% 27.21%) regulated inflammatory mediators cytokines inhibiting NF-κB MAPK pathways. These alleviated amyloidogenesis impairment TLR4, MAPKs, PI3K/Akt, activating Sirt1 pathways thus blocking downstream translocation NF-κB, which offers nutritional preventive strategy for neuroinflammation diseases such Alzheimer's disease (AD).