Antidiabetic Effects of Lactobacillus casei Fermented Yogurt through Reshaping Gut Microbiota Structure in Type 2 Diabetic Rats

• DOI: 10.1021/acs.jafc.8b04874
• Publication Date: 2018-11-06T12:06:51Z
• Authors: Ling Qu; Junli Ren; Lei Huang; Bo Pang; Xu Liu; Xiaodong Liu; Baolong Li; Yujuan Shan
• Keywords: Lactobacillus casei

The viable bacterial strains in conventional yogurt are intolerant to bile acid, which consequently cannot survive the conditions and their beneficial bioactivities thus lost. We have previously shown that Lactobacillus casei Q14 ( Lac-Q14), a probiotic, has potential alleviate diabetes rats. Herein, we used Lac-Q14 as starter culture ferment explore mechanisms of bioactivity diabetic results showed improved blood glucose insulin level, lowered gene expression critical enzymes involved liver gluconeogenesis. Pyrosequencing an obvious change composition intestinal microbiota treated abundance 21 genera differed significantly between group group. Quite few short-chain fatty acid (SCFA)-producing bacteria were selectively enriched, along with increased concentrations SCFA downstream Glucagon-like peptide-1 (GLP-1) Peptide YY (PYY) secretion.