Green Tea Catechins Effectively Altered Hepatic Fibrogenesis in Rats by Inhibiting ERK and Smad1/2 Phosphorylation

• DOI: 10.1021/acs.jafc.8b05179
• Publication Date: 2018-11-14T02:29:28Z
• Authors: Liwen Wang; Guliang Yang; Li Yuan; Yiwen Yang; Hui Zhao; Chi-Tang Ho; Shiming Li
• Keywords: Liver Cirrhosis; 0301 basic medicine; 0303 health sciences; MAP Kinase Signaling System; Plant Extracts; Smad2 Protein; Camellia sinensis; Catechin; Rats; Smad1 Protein; Rats, Sprague-Dawley; 03 medical and health sciences; Liver; Transforming Growth Factor beta; Animals; Humans; Female; Phosphorylation

Polyphenols derived from green tea have been reported to a wide range of profound functions. Tea catechins, including epicatechin, epigallocatechin (EGC), epicatechin-3-O-gallate (ECG), and epigallocatechin-3-O-gallate (EGCG), are considered as the major bioactive polyphenols in tea. The present study was designed elucidate potential antifibrogenic role three abundant catechins (ECG, EGC, EGCG) CCl4-induced fibrotic rat their underlying molecular mechanisms. especially groups ECG, EGCG, effectively induced several beneficial alterations liver injury markers, oxidative status, histology. Furthermore, ameliorated fibrosis, evidenced by reduced expression desmin, α-smooth muscle actin, transforming growth factor β (TGF-β), downstream ERK1/2 Smad1/2 phosphorylation. most significant inhibitory effect on those proteins observed ECG (300 mg/kg) EGCG groups. In addition, conferred protective downregulating proinflammation cytokines TGF-β, tumor necrosis α, interleukin 17. It is postulated that particularly therapeutic candidates antifibrotic therapy.