Delivery of Sesamol Using Polyethylene-Glycol-Functionalized Selenium Nanoparticles in Human Liver Cells in Culture

• DOI: 10.1021/acs.jafc.8b06924
• Publication Date: 2019-02-19T17:51:00Z
• Authors: Fuguo Liu; Hua Liu; Runhua Liu; Chunxia Xiao; Xiang Duan; David Julian McCl...; Xuebo Liu
• Keywords: Sesamol

Anticancer nanoparticles were fabricated by linking the of two known anticancer agents, sesamol and selenium, using polyethylene glycol (PEG). The successful fabrication sesamol–PEG–selenium (PEG–SeNPs), which had a loading efficiency 10.0 ± 0.5 wt %, was demonstrated different spectroscopic techniques. impact on model cancer cells (HepG2) established cell activity test, morphological observation, fluorescent staining, all showed that effectively inhibited HepG2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays concentration sample inhibits 50% PEG–SeNPs sesamol–PEG–SeNPs 413.8 68.7 μg/mL, respectively, indicated synergistic inhibition between selenium nanoparticles. Furthermore, flow cytometry exhibited higher apoptosis than either or alone. Finally, western blot confirmed apoptostic ability associated with downregulation Bcl-2 procaspase-3, upregulation Bax PARP, discharge cytochrome c into cytosol. Our findings suggest novel may be efficient agents.