Cyclase-Associated Protein Cap with Multiple Domains Contributes to Mycotoxin Biosynthesis and Fungal Virulence in Aspergillus flavus

• DOI: 10.1021/acs.jafc.8b07115
• Publication Date: 2019-03-27T23:57:42Z
• Authors: Kunlong Yang; Yinghang Liu; Sen Wang; Lianghuan Wu; Rui Xie; Huahui Lan; Opemipo Esther Fa...; Yu Wang; Shihua Wang
• Keywords: Conidiation; Spore germination; Gliotoxin; Fungal protein; Aspergillus nidulans

In Aspergillus, the cyclic adenosine monophosphate (cAMP) signaling modulates asexual development and mycotoxin biosynthesis. Here, we characterize cyclase-associated protein Cap in pathogenic fungus Aspergillus flauvs. The cap disruption mutant exhibited dramatic reduction hyphal growth, conidiation, spore germination, while an enhanced production of sclerotia was observed this mutant. Importantly, gene found to be important for biosynthesis virulence. domain deletion study demonstrated that each played role regulating cAMP/protein kinase A (PKA) signaling, only P1 CARP domains were essential full function Cap. phosphorylation at S35 identified A. flavus, which play a negligible Overall, our results indicated with multiple engages fungal pathogenicity, could designed as potential control targets preventing pathogen.