Systemic Stereoselectivity Study of Etoxazole: Stereoselective Bioactivity, Acute Toxicity, and Environmental Behavior in Fruits and Soils

• DOI: 10.1021/acs.jafc.9b01257
• Publication Date: 2019-05-29T13:28:49Z
• Authors: Weixia Chang; Jiyun Nie; Zhen Yan; Yujiao Wang; Saqib Farooq
• Keywords: 0301 basic medicine; Stereoisomerism; Fragaria; 01 natural sciences; 6. Clean water; 0104 chemical sciences; 3. Good health; Soil; 03 medical and health sciences; Fruit; Malus; Animals; Soil Pollutants; Vitis; Tetranychidae; Oxazoles; Acaricides

This is the first systemic assessment of stereoselectivity etoxazole enantiomers. Etoxazole's stereoselective bioactivity was assessed against target organisms ( Tetranychus urticae eggs and cinnabarinus eggs), its acute toxicity toward nontarget aquatic Daphnia magna Danio rerio). Additionally, elimination investigated in three species fruits (grape strawberry grown a greenhouse apple an open field) field soil. The ovicidal activity (+)-( S)-etoxazole about 16 24 times higher, respectively, than that (-)-( R)-etoxazole. Inconsistent order isomer found different organisms: showed nearly 8.7 higher R)-etoxazole magna, whereas ∼4.5 more toxic to rerio S)-etoxazole. Stereoselective degradation enantiomers significant variation various preferentially dissipated grape under condition, degraded faster antipode soils open-field condition. Overall, should be fully considered comprehensive environmental health risk future work.