Skeletocutins A-L: Antibacterial Agents from the Kenyan Wood-Inhabiting Basidiomycete, Skeletocutis sp.

• DOI: 10.1021/acs.jafc.9b02598
• Publication Date: 2019-07-16T12:43:06Z
• Authors: Clara Chepkirui; Tian Cheng; Winnie Chemutai Sum; Josphat Clement M...; Cony Decock; Dimas F. Praditya; Kathrin Wittstein; Eike Steinmann; Marc Stadler
• Keywords: Infectivity

Fermentation of the fungal strain Skeletocutis sp. originating from Mount Elgon Natural Reserve in Kenya, followed by bioassay guided fractionation led to isolation 12 previously undescribed metabolites named skeletocutins A-L (1-5 and 7-13) together with known tyromycin A (6). Their structures were assigned NMR spectroscopy complemented HR-ESIMS. Compounds 1-6 11-13 exhibited selective activities against Gram-positive bacteria, while compound 10 weakly inhibited formation biofilm Staphylococcus aureus. The isolated also evaluated for inhibition L-leucine aminopeptidase, since had been reported possess such but only showed weak effects. Furthermore, all compounds tested antiviral activity Hepatitis C virus (HCV), 6 moderately HCV infectivity an IC50 6.6 μM.