l-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice

• DOI: 10.1021/acs.jafc.9b05829
• Publication Date: 2019-11-01T14:23:28Z
• Authors: Yan Li; Haiou Pan; Jin-xin Liu; Tingting Li; Shengnan Liu; Wenli Shi; Chao Sun; Mingcong Fan; Lamei Xue; Yu Wang; Chenzhipeng Nie; Hui Zhang; Haifeng Qian; Hao Ying; Li Wang
• Keywords: Arabinose

l-Arabinose is a monosaccharide extracted from plants or fibers, which known to have variety of functional properties. In this study, we aim investigate whether l-arabinose could inhibit colitis by modulating gut microbiota. was administered in mice daily dextran sodium sulfate (DSS)-induced model. The histological analysis, disease index, and the expression inflammatory genes were measured. 16S-rRNA sequence analysis performed Intriguingly, found that repress DSS-induced p38-/p65-dependent inflammation activation. Besides that, our data revealed l-arabinose-modulated microbiota disturbed. Additionally, perturbed responsible for suppressive effects on treated with antibiotics. Lastly, Caco-2 cells used confirm protective bowel disease. As expected, protein levels pro-inflammatory genes, incubated without tumor necrosis factor alpha. Our work suggested exerts anti-inflammation colitis. These beneficial correlations composition, diversity, abundance regulated l-arabinose. be remarkable candidate as food novel therapeutic strategy intestinal health.