Inhibitory Effects of Walnut (Juglans regia) Peptides on Neuroinflammation and Oxidative Stress in Lipopolysaccharide-Induced Cognitive Impairment Mice

• DOI: 10.1021/acs.jafc.9b07670
• Publication Date: 2020-02-09T15:46:37Z
• Authors: Shuguang Wang; Lin Zheng; Tiantian Zhao; Qi Zhang; Yang Liu; Baoguo Sun; Guowan Su; Mouming Zhao
• Keywords: Proinflammatory cytokine

Increasing level of inflammation and oxidative stress could lead to memory impairment. The purpose this study was determine the neuroprotective effects walnut peptides against deficits induced by lipopolysaccharide (LPS) in mice further explore underlying anti-inflammatory mechanisms LPS-elicited BV-2 cells. Results showed that protein hydrolysate (WPH) its low-molecular-weight fraction (WPHL) ameliorate LPS via normalizing inflammatory response brain, especially WPHL. Furthermore, 18 with activities on LPS-activated cells were identified from WPHL it found Trp, Gly, Leu residues might contribute anti-inflammation. Meanwhile, strong LPF, GVYY, APTLW be related their hydrophobic aromatic amino acid as well. reduce content proinflammatory mediators cytokines downregulating enzyme expressions mRNA expressions. Additionally, ROS mitochondria homeostasis also effects.