Measurement, Solvent Effect, and Thermodynamic Modeling of the Solubility of Benzohydrazide and 2-Hydroxybenzohydrazide in Six Pure Solvents

• DOI: 10.1021/acs.jced.4c00217
• Publication Date: 2024-08-16T16:54:31Z
• Authors: Adel Noubigh; Hammadi Khmissi; Manef Abderrabba
• Keywords: Gravimetric analysis

Benzohydrazide (BH) and 2-hydroxybenzohydrazide (HBH) have gained attention due to their diverse characteristics wide applications in pharmacy organic synthesis. In this study, a gravimetric technique was used measure the ability of BH HBH dissolve six monosolvents [water, methanol (MeOH), ethanol (EtOH), propan-1-ol (1-PrOH), propan-2-ol (2-PrOH), butan-1-ol (1-BuOH)] at an atmospheric pressure 0.1 MPa. The solubility measured temperature range 288.15–328.15 5 K intervals. It is revealed that based on temperature, rises with increase temperature. dissolves from high low following order: water < 1-BuOH 2-PrOH 1-PrOH EtOH MeOH, while for HBH, it > MeOH 1-BuOH. solvent effects, which account connections between solute, were studied using linear solvation energy relationship. solubilities successfully correlated modified Apelblat equation, van't Hoff NRTL, Wilson models, λh equation. values calculated these models aligned experimental solubility. highest relative average deviation root-mean-square 21.30 × 10–4 4.04% (λh equation) 11.62 6.09% (NRTL model), respectively. Also, model data utilized evaluate mixing thermodynamic properties BH, including excess Gibbs free enthalpy.