Polypharmacology of N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential

• DOI: 10.1021/acs.jmedchem.7b00805
• Publication Date: 2017-08-11T12:54:00Z
• Authors: Jinha Yu; Seyeon Ahn; Hee Jin Kim; Moonyoung Lee; Sungjin Ahn; Jungmin Kim; Sun Hee Jin; Eunyoung Lee; Gyudong Kim; Jae Hoon Cheong; Kenneth A. Jacobson; Lak Shin Jeong; Minsoo Noh
• Keywords: Male; 0301 basic medicine; Adenosine; Polypharmacology; Receptor, Adenosine A3; Adenosine A3 Receptor Antagonists; Ligands; Cell Line; Diabetes Mellitus, Experimental; Mice, Inbred C57BL; PPAR gamma; Mice; 03 medical and health sciences; Adenosine A3 Receptor Agonists; Animals; Humans; Hypoglycemic Agents; Adiponectin; PPAR delta; Insulin Resistance

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