Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes

• DOI: 10.1021/acs.jnatprod.0c01069
• Publication Date: 2021-01-05T07:20:56Z
• Authors: Meri Emili F. Pinto; Lai Yue Chan; Johannes Koehbach; Seema Devi; Carsten Gründemann; Christian W. Gruber; Mario Gomes; Vanderlan S. Bolzani; Eduardo Maffud Cilli; David J. Craik
• Keywords: Violaceae; Cyclic peptide

Cyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone six conserved cysteine residues linked by disulfide bonds. Their presence the Violaceae species seems ubiquitous, yet not all members other produce these macrocyclic peptides. The genus