Fe(III)-Catalyzed Decarboxylative C3-Difluoroarylmethylation of Coumarins with α,α-Difluoroarylacetic Acids

• DOI: 10.1021/acs.joc.0c00113
• Publication Date: 2020-05-21T11:37:22Z
• Authors: Zhiwei Chen; Xiang Bai; Jie Sun; Yicheng Xu
• Keywords: Simplicity

A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series C-3 difluoroarylmethylated containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.