Site-Selective Aerobic C–H Monoacylation of Carbazoles Using Palladium Catalysis

• DOI: 10.1021/acs.joc.0c01746
• Publication Date: 2020-12-31T16:12:32Z
• Authors: Subhadip Maiti; Tirtha Mandal; Barada Prasanna Dash; Jyotirmayee Dash
• Keywords: Dual role

This manuscript describes the development of a remarkably general palladium-catalyzed monoacylation carbazoles using toluene derivatives playing dual role acyl source and organic solvent. The method uses NHPI as cocatalyst oxygen sole oxidant. Interestingly, acylation monosubstituted N-pyridylcarbazoles takes place regioselectively at C-8 position. scope is explored aldehyde source. highly site-selective proceeds through radical process.