Ruthenium-Catalyzed Electrochemical Synthesis of Indolines through Dehydrogenative [3 + 2] Annulation with H2 Evolution

• DOI: 10.1021/acs.joc.0c01879
• Publication Date: 2020-10-13T16:31:15Z
• Authors: Haiwei Shen; Tao Liu; Didi Cheng; Xiao Yi; Ze Wang; Lei Liu; Dingguo Song; Fei Ling; Weihui Zhong
• Keywords: Annulation

A dehydrogenative [3 + 2] annulation reaction of aniline derivatives and alkenes has been developed via the ruthenium-electron catalytic systems for synthesis versatile indolines. Electricity is used as a sustainable oxidant to regenerate active Ru(II) catalyst promote H2 evolution. This protocol ecofriendly easy handle it uses simple undivided cell in mild conditions without employment metal oxidants.