Palladium-Catalyzed One-Pot Synthesis of Pyrroloindolines from 2-Alkynyl Arylazides and Thioacetamides

• DOI: 10.1021/acs.joc.1c01058
• Publication Date: 2021-07-20T05:51:02Z
• Authors: Ping Li; Fan Yang; Guiwen Hu; Xiaoxiang Zhang
• Keywords: Chemistry Techniques, Synthetic; Thioacetamide; 01 natural sciences; Catalysis; Palladium; 0104 chemical sciences

A novel and efficient synthetic method for the preparation of various pyrroloindolines from 2-alkynyl arylazides and thioacetamides was developed. The reaction was carried out in a one-pot process under mild reaction conditions to afford the products in moderate to good yields, which has the potential to be used in organic synthesis.