[DDQM][HSO4]/TBHP as a Multifunctional Catalyst for the Metal Free Tandem Oxidative Synthesis of 2-Phenylquinazolin-4(3H)-ones

• DOI: 10.1021/acs.joc.2c00908
• Publication Date: 2022-08-12T12:05:42Z
• Authors: Bidyutjyoti Dutta; Nilakshi Dutta; Apurba Dutta; Montu Gogoi; Sanjay Mehra; Arvind Kumar; Kalyanjyoti Deori; Diganta Sarma
• Keywords: Benzyl alcohol; Tandem

A bifunctional ionic liquid (IL) [DDQM][HSO4] has been designed and explored as a three-way catalyst for the synthesis of 2-phenylquinazolin-4(3H)-ones from anthranilamide benzyl alcohol in 3.5 min incorporating microwave irradiation. Photochemically reaction proceeds 4 h at room temperature thermally 8 120 °C. Further IL-assisted metal, solvent, base free situ oxidation alcohols to aldehydes shows its task specificity. The multifunctionality IL was reestablished with two Wnt pathway antagonists.