Carboxylic Acid O–H Insertion Reaction of β-Ester Diazos Enabling Synthesis of β-Acyloxy Esters

• DOI: 10.1021/acs.joc.2c02023
• Publication Date: 2022-11-10T10:56:06Z
• Authors: Ziyi Li; Xinyu Yao; Xin Zhang; Haibo Mei; Jianlin Han
• Keywords: Insertion reaction; Reaction conditions; Natural product

Generation of non-stabilized β-ester diazos and their applications in carboxylic acid O–H insertion reactions have been reported, which afford β-acyloxy esters excellent yield. Varieties aryl- alkyl-substituted are well tolerated this reaction under mild convenient conditions. Moreover, structural modification the natural product molecular drug can also be achieved reaction. This protocol not only realizes involving unstable but provides an efficient strategy for synthesis esters.