Copper-Promoted Aerobic Oxidative [3+2] Cycloaddition Reactions of N,N-Disubstituted Hydrazines with Alkynoates: Access to Substituted Pyrazoles

• DOI: 10.1021/acs.joc.2c02610
• Publication Date: 2023-02-01T16:56:25Z
• Authors: Xiaoying Zou; Lvyin Zheng; Xiaoya Zhuo; Yumei Zhong; Yingying Wu; Beining Yang; Qifang He; Wei Guo
• Keywords: Atom economy; Surface Modification

A copper-promoted aerobic oxidative [3+2] cycloaddition reaction for the synthesis of various substituted pyrazoles from N,N-disubstituted hydrazines with alkynoates in presence bases is developed. This work involves a direct C(sp3)-H functionalization and formation new C-C/C-N bonds. In this strategy, inexpensive easily available Cu2O serves as promoter air acts green oxidant. The exhibits advantages high atom step economy, regioselectivity, easy operation.