Photoinduced Decarboxylative C3–H Alkylation of Quinoxalin-2(1H)-ones

• DOI: 10.1021/acs.joc.2c02823
• Publication Date: 2023-02-03T14:16:21Z
• Authors: Akash Bisoyi; Alisha Rani Tripathy; Girish Suresh Yedase; Shifana Sinu P; Udita Choudhury; Veera Reddy Yatham
• Keywords: Reaction conditions; Functional group

An efficient, catalyst- and additive-free, visible-light-driven radical C3-H alkylation of quinoxalin-2(1H)-one derivatives has been developed. This reaction utilizes alkyl-NHP-esters as an alkyl donor acceptor. The operationally simple protocol works under mild conditions tolerates a variety functional groups. Furthermore, the synthetic utility methodology was successfully implemented for synthesizing biologically relevant C3-alkyl substituted derivatives.