Copper-Catalyzed Synthesis of α-Keto Amides from Sulfoxonium Ylides

• DOI: 10.1021/acs.joc.3c00281
• Publication Date: 2023-05-24T11:34:25Z
• Authors: Xinghua Wang; Yazhou Li; Naixuan Zhao; Hong Liu; Yu Zhou
• Keywords: Amines; Amides; Copper; Catalysis

We here described a method to synthesize α-keto amides from simple sulfoxonium ylides and secondary amines under the catalysis of copper. This transformation involved a very simple and clean catalytic system, and the substrates could be extended to aryl, heteroaryl, and tert-butyl sulfoxonium ylides to give diversified α-keto amides with good yields. Additionally, the mechanistic studies indicated that the α-carbonyl aldehyde might be a key intermediate in the reaction system.