Pd(II)-Catalyzed Cascade Annulation of o-Aminobenzoic Acids with CO, Amines, and Aldehydes to N3-/N1,N3-Substituted 2,3-Dihydroquinazolin-4(1H)-ones

• DOI: 10.1021/acs.joc.3c00802
• Publication Date: 2023-07-07T19:06:00Z
• Authors: Xiaopeng Zhang; Jinjun Wang; Jiahui Xu; Qiuyang Pang; Dan Liu; Guisheng Zhang
• Keywords: Annulation

The unprecedented Pd(II)-catalyzed cascade annulation of o-aminobenzoic acids with CO, amines, and aldehydes has been developed. This protocol provides an efficient concise approach to selective construction N3-substituted N1,N3-disubstituted 2,3-dihydroquinazolin-4(1H)-ones mostly in moderate excellent yields from simple easily available starting materials under mild conditions featured low cost, high step economy, broad substrate scope, good product diversity.