Green Oxidation of Heterocyclic Ketones with Oxone in Water

• DOI: 10.1021/acs.joc.3c01513
• Publication Date: 2023-10-12T14:43:01Z
• Authors: Alessandro Giraudo; Edoardo Armano; Camillo Morano; Marco Pallavicini; Cristiano Bolchi

The recently reported efficient conversion of cyclic ketones to lactones by Oxone in neutral buffered water is extended heterocyclic ketones, namely, N-Boc azaketones and oxoethers with the aim obtaining N-protected azalactones their analogues oxygen place nitrogen. N-Boc-4-piperidinone all were successfully oxidized lactones, while azacyclic nitrogen α-positioned carbonyl univocally transformed into N-Boc-ω-amino acids N-Boc-N-formyl-ω-amino operating alkaline DMF, respectively.