Synthesis of Charge-Compensated nido-Carboranyl Derivatives of Sulfur-Containing Amino Acids and Biotin

• DOI: 10.1021/acs.joc.3c01569
• Publication Date: 2023-09-22T13:52:30Z
• Authors: Dmitry A. Gruzdev; Angelina A. Telegina; Galina L. Levit; Marina A. Ezhikova; Mikhail I. Kodess; Victor P. Krasnov
• Keywords: Carborane; Boranes

A new group of charge-compensated nido-carboranyl derivatives sulfur-containing amino acids and biotin has been synthesized in which the boron atom position 9 or 10 carborane is attached to a positively charged sulfur atom. The possibilities obtaining symmetrical B(10)-substituted asymmetric B(9)-substituted nido-carboranes were studied. Using example (S)-methionine D-biotin derivatives, water-soluble S-substituted with free functional groups prepared. results obtained open up prospects for development potential delivery agents BNCT as well bioactive compounds containing negatively fragment bearing positive charge on associated cluster.