Synthesis of Acylhydroquinones through Visible-Light-Mediated Hydroacylation of Quinones with α-Keto Acids

• DOI: 10.1021/acs.joc.3c02361
• Publication Date: 2024-01-11T07:56:36Z
• Authors: Ben Ma; Yawen Gong; Yun’e Long; Zhiyong Chen; Yong Yuan; Jingya Yang
• Keywords: Hydroacylation; Visible spectrum

A mild and eco-friendly visible-light-induced protocol for the hydroacylation of quinones with α-keto acids has been developed. In absence any catalyst or additive, decarboxylative proceeded smoothly under visible-light irradiation at room temperature. wide range were well-tolerated afforded products up to 88% isolated yield. The reaction can be scaled up, induced groups are useful further synthetic applications. Preliminarily, mechanistic studies indicated that photoactive absorb visible light facilitate transformation.