Three-Component Reaction between 3-Acetylcoumarins, Amines, and Elemental Sulfur: A Designed Approach to 3-Amino-4H-thieno[3,2-c]coumarins

• DOI: 10.1021/acs.joc.3c02406
• Publication Date: 2024-03-12T15:30:22Z
• Authors: Behnaz Farajpour; Roujin Heydarzadeh; Faiq H. S. Hussain; Behrouz Notash; Peiman Mirzaei; Morteza Shiri
• Keywords: Component (thermodynamics); Functional group

In this work, a series of novel 3-amino-4H-thieno[3,2-c]coumarins were designed and synthesized by one-pot, catalyst-free, three-component reaction 3-acetylcoumarins with amines elemental sulfur. Readily available starting materials, simple heating conditions, facile installation sulfur atom into the molecule using S8 as source, acceptable functional group tolerance, synthetically useful yields are some highlighted benefits process.