Semipinacol Rearrangement of Iododifluorohomoallyl Alcohols and Its Application in the Allylic C–H Esterification Reactions

• DOI: 10.1021/acs.joc.3c02559
• Publication Date: 2024-02-12T06:57:02Z
• Authors: Junqi Wang; Jihong Wu; Ruowen Li; Kaiji Wang; Shibo Xu; Jingjing Wu; Fanhong Wu
• Keywords: Catalytic cycle

We herein present a study on the Ag(I)-mediated semipinacol rearrangement of iododifluorohomoallyl alcohols, resulting allylic difluoromethyl ketones underwent oxidative C-H esterification under palladium catalysis in absence external ligand. This process yielded range derived from allyl esters single operation. The reaction features broad scope