Hypervalent Iodine Promoted Selective [2 + 2 + 1] Cycloaddition of Aromatic Ketones and Methylamines: A One-Pot Access to 1-Pyrrolines

• DOI: 10.1021/acs.joc.4c00830
• Publication Date: 2024-07-09T20:45:06Z
• Authors: Lipeng Long; Xin Li; Ziwen Huang; Ziyi Yu; Daohong Yu; Wenjun Luo; Liang Qiao; Zhengwang Chen; Zhong-Xia Wang
• Keywords: Methylamines; Hypervalent molecule

Herein, a versatile highly regioselective three-component annulation of simple aromatic ketones and methylamines using hypervalent iodine reagent for polyarylated 1-pyrrolines has been described in good to excellent yields. Meanwhile, unsymmetrical 1-pyrroline isomers could be realized synthesized. Such an intriguing one-pot two-step tandem assembly strategy with green conditions high regioselectivity shows predictable inspiration related reactions.