Diastereoselective Synthesis of syn-β-Lactams Using Rh-Catalyzed Reductive Mannich-Type Reaction of α,β-Unsaturated Esters

• DOI: 10.1021/acs.joc.5b01233
• Publication Date: 2015-07-23T16:06:45Z
• Authors: Motoyuki Isoda; Kazuyuki Sato; Masato Funakoshi; Keiko Omura; Atsushi Tarui; Masaaki Omote; Akira Ando
• Keywords: Molecular Structure; Esters; Rhodium; Stereoisomerism; beta-Lactams; 01 natural sciences; Catalysis; 0104 chemical sciences

AbstractReaction conditions are optimized for the Rh‐hydride complex catalyzed reaction of α,β‐unsaturated esters with imines to give syn‐3,4‐disubstituted β‐lactams.