Catalyst-Free Regioselective C-3 Thiocyanation of Imidazopyridines

• DOI: 10.1021/acs.joc.5b01637
• Publication Date: 2015-10-02T17:20:41Z
• Authors: Daoshan Yang; Kelu Yan; Wei Wei; Guoqing Li; Shenglei Lu; Caixia Zhao; Laijin Tian; Hua Wang
• Keywords: Imidazopyridine; Surface Modification; Reaction conditions

A direct and straightforward approach for highly regioselective thiocyanation of imidazoheterocycles through sp2 C–H functionalization has been realized at room temperature. Various C-3 thiocyanated imidazopyridines are formed in moderate to good yield. The present method exhibits a mild selective access variety imidazopyridine derivatives pharmacological interest.