Total Synthesis of (−)-Hymenosetin

• DOI: 10.1021/acs.joc.5b02526
• Publication Date: 2015-12-04T22:39:08Z
• Authors: Ulrich Kauhl; Lars Andernach; Stefan Weck; Louis P. Sandjo; Stefan Jacob; Eckhard Thines; Till Opatz
• Keywords: Biological Products; Cycloaddition Reaction; Molecular Structure; Stereoisomerism; 01 natural sciences; Pyrrolidinones; 0104 chemical sciences

AbstractHymenosetin (I) and its N‐methyl analogue are prepared in 11 and 8 steps, respectively, from citronellal employing an intramolecular Diels‐Alder reaction as the key step.