Preparation of Optically Pure Tertiary Phosphine Oxides via the Addition of P-Stereogenic Secondary Phosphine Oxide to Activated Alkenes

• DOI: 10.1021/acs.joc.6b01371
• Publication Date: 2016-07-27T22:42:47Z
• Authors: Ji-Ping Wang; Shao-Zhen Nie; Zhong-Yang Zhou; Jing-Jing Ye; Jing-Hong Wen; Chang-Qiu Zhao
• Keywords: Stereocenter; Phenylphosphine; Phosphine oxide

Functionalized P,C-stereogenic tertiary phosphine oxides were prepared by the addition of (RP)-menthyl phenylphosphine oxide to activated olefins, in high drP and drC, isolated excellent yields. The reaction was readily catalyzed Ca(OH)2 or occurred with gentle heating. A wide range substrates, including vinyl ketones, esters, nitriles, nitro alkenes, can be used reaction.