Base-Promoted Intermolecular Cyclization of Substituted 3-Aryl(Heteroaryl)-3-chloroacrylaldehydes and Tetrahydroisoquinolines: An Approach to Access Pyrrolo[2,1-a]isoquinolines

• DOI: 10.1021/acs.joc.6b01781
• Publication Date: 2016-11-02T00:53:17Z
• Authors: Ziqi Yang; Ning Lu; Zhonglin Wei; Jungang Cao; Dapeng Liang; Haifeng Duan; Yingjie Lin
• Keywords: Base (topology)

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The provides facile practical synthesis pyrrolo[2,1-a]isoquinolines. A number pyrrolo[2,1-a]isoquinolines were synthesized moderate to high yields (up 97%).