One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine

• DOI: 10.1021/acs.joc.6b03084
• Publication Date: 2017-03-03T09:27:47Z
• Authors: Alexander V. Aksenov; Dmitrii A. Aksenov; Naila A. Orazova; Nicolai A. Aksenov; Georgii D. Griaznov; Annelise De Carvalho; Robert Kiss; Véronique Mathieu; Alexander Kornienko; Michael Rubin
• Keywords: Component (thermodynamics); Condensation reaction

Indolo[3,2-c]quinolones have been efficiently synthesized via an acid-mediated, one-pot, three-component condensation of arylhydrazines, o-aminoacetophenones, and triazines or nitriles. The synthetic application this method is showcased by the concise synthesis isocryptolepine alkaloid a series its analogues with demonstrated cancer cell antiproliferative activities.