Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions

• DOI: 10.1021/acs.joc.7b01855
• Publication Date: 2017-10-19T19:16:45Z
• Authors: Saeed Balalaie; Reihaneh Ramezani...; Elmira Ghabraie; Fatemeh Darvish; Frank Rominger; Fatima Hamdan; Hamid Reza Bijanz...
• Keywords: Diketopiperazines; Sequence (biology)

A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry library of under mild conditions in good excellent yields.