Diastereoselective Synthesis of Functionalized Diketopiperazines through Post-transformational Reactions

Diketopiperazines Sequence (biology)
DOI: 10.1021/acs.joc.7b01855 Publication Date: 2017-10-19T19:16:45Z
ABSTRACT
A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry library of under mild conditions in good excellent yields.
SUPPLEMENTAL MATERIAL
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