C(5) Site-Selective Functionalization of (S)-Cotinine

• DOI: 10.1021/acs.joc.7b02704
• Publication Date: 2017-12-05T23:53:14Z
• Authors: Hugo Rego Campello; Timothy Gallagher
• Keywords: 530; 01 natural sciences; 3. Good health; 0104 chemical sciences

(S)-(-)-Cotinine 2 undergoes direct and site-selective iridium-catalyzed borylation to provide boronate ester 3 and bromide 4 which offer flexible entry to a range of C(5)-substituted cotinine variants.