Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.

• DOI: 10.1021/acs.joc.8b00028
• Publication Date: 2018-02-20T16:55:25Z
• Authors: Yiwen Tao; Pinglin Li; Daojing Zhang; Evgenia Glukhov; Lena Gerwick; Chen Zhang; Thomas F. Murray; William H. Gerwick
• Keywords: Cancer cell lines; Natural product

Cancer cell cytotoxicity was used to guide the isolation of nine new swinholide-related compounds, named samholides A–I (1–9), from an American Samoan marine cyanobacterium cf. Phormidium sp. Their structures were determined by extensive analysis 1D and 2D NMR spectroscopic data. The compounds share unusual 20-demethyl 44-membered lactone ring composed two monomers, they demonstrate structural diversity arising geometric isomerization double bonds, sugar units with unique glyceryl moieties varied methylation patterns. All potently active against H-460 human lung cancer line IC50 values ranging 170 910 nM. these a reinvigorates questions concerning evolution biosynthetic origin natural products.