Transition-Metal-Free C–P Bond Formation via Decarboxylative Phosphorylation of Cinnamic Acids with P(O)H Compounds

• DOI: 10.1021/acs.joc.8b00187
• Publication Date: 2018-03-02T11:03:28Z
• Authors: Lixin Liu; Dan Zhou; Jianyu Dong; Yongbo Zhou; Shuang-Feng Yin; Li-Biao Han
• Keywords: Decarboxylation; Cinnamic acid

A novel, transition-metal-free phosphorylation of cinnamic acids with P(O)H compounds has been developed via radical-promoted decarboxylation under mild conditions. This method provides simple, efficient, and versatile access to valuable (E)-alkenylphosphine oxides in satisfactory yields a wide variety substrates.