Self [3 + 4] Cycloadditions of Isatin N,N′-Cyclic Azomethine Imine 1,3-Dipole with N-(o-Chloromethyl)aryl Amides

• DOI: 10.1021/acs.joc.8b01055
• Publication Date: 2018-05-30T15:03:44Z
• Authors: Qiaomei Jin; Jian Zhang; Cuihua Jiang; Dongjian Zhang; Meng Gao; Shihe Hu
• Keywords: Isatin; Imine; Annulation

A [3 + 4] annulation of isatin N,N′-cyclic azomethine imine 1,3-dipole 1 with in situ-generated aza-oQMs has been established for the synthesis spirooxindole seven-membered scaffolds. These highly functionalized scaffolds were assembled moderate to good yields (up 96% yield). The novel displayed antitumor activities, which represented promising lead compounds drug discovery.